Theory associated with bob knowlton case

While this emphasis still provides a strong motivation for the more recent studies of respiratory mechanics, in the modern era, the primary objective of many studies is often the mechanical properties themselves.

Interest and work associated with respiratory mechanics prior to the 20th century generally arose as part of a broader emphasis either on a clinical disease or general physiological principles. In this chapter, we will consider more recent aspects of respiratory mechanics as they involve quantitative, physical, and physiological principles and analyses in the study of the lungs. The history of respiratory mechanics covers an enormous area, and much of the early and ancient history with additional source material is covered elsewhere ( 180). From the spirometer of Hutchinson, to the pneumotachograph of Fleisch, to the measurement of esophageal pressure, to the use of the Wilhelmy balance by Clements, to the unassuming strain gauges for measuring pressure and rapid paper and electronic chart recorders, these enabling devices have generated numerous quantitative experimental studies with greatly increased physiologic understanding and validation of mechanistic theories of lung function in health and disease. This situation changed rapidly in the 20 th century, and this relatively recent history of lung mechanics has been greatly influenced by critical technological advances and applications, which have made quantitative experimental testing of ideas possible.

The earliest and ancient investigations involving respiratory physiology and mechanics were often done in conjunction with other scientific activities and often lacked the ability to make quantitative measurements. Major advances in respiratory mechanics occurred primarily in the latter half of the 20 th century, and this is when much of our current understanding was secured.

Theory associated with bob knowlton case

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